Effective and Safe oral Chelation:

what does chelation mean?

Types of chelation agents used by dr. bolte:

safety and approval of dmsa and dmps:

what are the benefits of chelation therapy?

what are the potential dangers of toxic metals?

why it is important to rid our bodies of free radicals?

why oral chelation?

how to determine if you have heavy metal poisoning?

WHAT DOSE CHELATION MEAN?

   The word Chelation is derived from the Greek word Chele that means claw.  When an effective chelating agent comes in contact with a positively charged metal it grabs them like a claw and removes them through the kidneys.  Thus Chelation is the therapy or process of removing undesirable heavy metals from the body. 

TYPES OF CHELATION AGENTS:

  DMSA / DMPS are oral chelating agents that are recognized antidotes for detoxifying metals such as: Antimony, Arsenic, Bismuth, Cadmium, Lead and Mercury.  Magnesium glucamate has been shown effective for removal of Aluminum out of the body.  Both DMSA (Meso-2,3-dimercatptosuccinic acid) and DMPS (2,3-dimercapto-1-propanesulfonic acid Na salt) have been well studied on a basic scientific and clinical level for over 50 years.

 SAFETY AND APPROVAL OF DMSA AND DMPS:

  Currently, DMSA (tradename Succimer) is FDA approved for lead detoxification in children. DMPS (trademark Dimaval), on the other hand, is not an approved drug in the United Stated or Canada, but it is on the US FDA list as bulk substances that may be used in pharmacy compounding and is used widely by US physicians for metal detoxification.  DMPS has been distributed and used in Europe since 1976 and West Germany has utilized DMPS as treatment of choice for more than ten years and valued it for its minor side effects like nausea, weakness, vertigo, skin itching, and diuresis.

  Numerous studies show DMSA (Succimer) ability to increase urinary excretion of lead and mercury and decrease levels in the blood.  There is also evidence that DMSA provocation in conjunction with other challenge agents, helps to boost cumulative metal excretion and prevent redistribution of lead and mercury to the soft tissues.  DMSA has also been noted to remove metals from brain in animal models.  There are several advantages to the use of DMSA in that it is generally well tolerated with the occasional gastrointestinal or dermatological side effect, and has minimal effect on the excretion of essential minerals. 

WHAT ARE THE BENEFITS OF CHELATION THERAPY?

  Many scientists suggest that the beneficial effect of chelation treatment is from the removal of toxic metals that causes excessive free radical proliferation through out the body.  This reduces the oxidation of lipids, DNA, enzyme systems, and lipoproteins.  As a result burning of holes in our cellular membranes through out the body occur which in turn, weakens tissues and organs.  As this damage continues, our body becomes less able to fight other invaders such as cancer, infection, hardening of the arteries, premature aging and other bodily disorders.  The chelation and secreting of these aggressive metals halts the bad effects of excessive free radical damage and initiates strengthening of the body’s healing process, often reversing the damage that has occurred. 

 In other words, chelation of heavy metals can:

• Decrease in free-radical activity and oxidation process
• Promotes anti aging
• Strengthen the immune system
• Linked to prevention and reversal of learning disorders and neuro-degenerative disease
• Enhance cardiovascular (heart) functions
• Decrease the risk of cancer

  Research over the past 30 years has confirmed the benefits of DMSA/DMPS chelating agents.  This protective influence of eliminating toxic metals through chelation would be enhanced by an appreciable presence of antioxidant nutrients such as Vitamins A, C, essential fatty acids, selenium, and amino acid complexes such as glutathione peroxidase.

WHAT ARE THE POTENTIAL DANGERS OF TOXIC METALS?

• Aluminum and Mercury can bind and accumulate in brain tissue affecting proper brain functions.  They have been found in high concentrations and should be considered in degenerative neuro-diseases such as:  Presenile Dementia,  Alzheimer’s, Parkinson’s, and ALS.  Also,  are observed and with children and adults with behavioral/learning disorders such as ADD, ADHD, and autism.  Early symptoms of Aluminum excess include: fatigue and headache.
  
• Arsenic excess can cause malaise, muscle weakness, diarrhea, dermatitis, and skin cancer.  Arsenic, Tin and Silver excess can cause hormonal imbalances, early menopause and cardiovascular disease.
  
• Bismuth excess can cause the symptoms of constipation or bowel irregularity, foul breath, blue/black gum line, and malaise.  High levels can result in kidney damage, memory loss, and neurological disorders.
  
•  Cadmium excess is associated with hypertension, anemia, fatigue, osteomalacia, weight loss, and lumbar pain.
  
• Copper excess is associated to biliary obstruction, liver disease, and renal dysfunction.  Associated symptoms are muscle and joint pain, depression, irritability, tremor, anemia learning disabilities, and behavioral disorders.
  
• Lead excess has a neurological and kidney toxic effect and interferes with heme biosynthesis.  In children it can cause hyperactivity and learning disabilities. Symptoms associated with its excess are loss of appetite, poor memory, fatigue, constipation, headaches-, inability to concentrate and decreased coordination.
  
• Mercury and associated to Chronic Fatigue Syndrome and Fibromyalgia, Acute Myocardial Infarctions.  Hallmark symptoms of excess mercury include: loss of appetite, decreased sensed of touch, hearing, and vision, fatigue, depression, emotional instability, peripheral numbness and tremors, poor memory and cognitive dysfunction, and neuromuscular disorders.
  
•  Uranium excess appears to be correlated to kidney toxicity, chronic fatigue, and all forms of cancer.
  
• Mercury and Antimony   One of the most perfect studies ever preformed was published in the American College of Cardiology.  Biopsy of the myocardial tissue and regular skeletal muscle from the leg tissue of 32 patients with heart disease was performed.  Results concluded a greater the ten thousand times more mercury and antimony in the heart tissue than skeletal muscle tissue of these same 32 patients with heart disease.
  
• Aluminum and mercury are found in high levels in the brain with leaning disorders and neurogenic disorders such as Alzheimer’s, Parkinson’s, ALS and dementia.
  
• Accumulation of metals in general is associated with premature aging and suppression and/or deregulation of the immune system.

WHY IT IS IMPORTANT TO RID OUR BODIES OF FREE RADICALS?

  Free radicals are the highly unstable compounds that attack, infiltrate, and thus injure vital cell structures.  Most stable chemical compounds in the body possess a pair of electrons.  Sometimes, one of the members of the electron pair gets stripped away.  The resulting compound (less one electron) is called a free radical.  This free radical must now also go around looking for another compound to steal an electron form to become complete and in turn the compound that its electron was just stolen from becomes a free radical and must due the same to become stable. This process goes on and on  and is also known as the oxidation process.  When an over accumulation of these free radicals occur, they can result in tremendous damage or oxidation to the delicate machinery of our cells.  This, in the excess results in the loss of our recuperative and regenerative abilities and thus, acceleration of the aging of our bodies.  Chelation and Anti-oxidants are the key to eliminate these free radicals and thus balancing the oxidative stress to the body.

WHY ORAL CHELATION?

• Proven effective.
• The cost to do oral chelation is only about a third of that compared to doing intravenous chelation.
• Oral chelation is in capsule form and thus doesn’t require being at the doctors’ office to be administered.

 HOW TO DETERMINE IF YOU HAVE HEAVY METAL POISONING?

 There are two effective ways to evaluate accumulations of lead, mercury, antimony, arsenic, and other metals in ones body. 

1. Perform a urine challenge test with the chelating agent DMSA or DMPS.  If the levels of the heavy metals in the urine are significantly elevated after the administration of the chelating agent in comparison to the levels of heavy metals in the urine prior to chelation administration, appropriate treatment is warranted. 
2. Performing a Hair Analysis to determine whether or not the accumulations of heavy metals are at toxic levels.